The SN74AXC1T45 is a single-bit noninverting bus transceiver that uses two separate configurable power-supply rails. The device is operational with both VCCA and VCCB supplies as low as 0.65 V. The A port is designed to track VCCA, which accepts any supply voltage from 0.65 V to 3.6V. The B port is designed to track VCCB, which also accepts any supply voltage from 0.65 V to 3.6V. The DIR pin determines the direction of signal propagation. With the DIR pin configured HIGH, translation is from Port A to Port B. With DIR configured LOW, translation is from Port B to Port A. The DIR pin is referenced to VCCA, meaning that its logic-high and logic-low thresholds track with VCCA. This device is fully specified for partial-power-down applications using the Ioff current. The Ioff protection circuitry ensures that no excessive current is drawn from or to an input, output, or combined I/O that is biased to a specific voltage while the device is powered down. The VCC isolation feature ensures that if either VCCA or VCCB is less than 100mV, both I/O ports enter a high-impedance state by disabling their outputs. The glitch suppression circuitry enables either supply rail to be powered on or off in any order, providing robust power sequencing performance.