The TPS4141-Q1 is a high-voltage, precision matched resistor divider with an integrated programmable-gain amplifier. The TPS4141-Q1 also integrates a high-voltage switch to allow for connecting or disconnecting the high-voltage sense pin. The device is designed for automotive and industrial applications which require accurate, high-voltage measurements. The TPS4141-Q1 programmable-gain amplifier supports four divider ratios using DIV0 and DIV1 inputs. DIV0 and DIV1 can be set to fixed divider ratios and can also dynamically change while in operation. This allows for matching the amplifier output (AOUT) to the full-scale input voltage of the analog-to-digital signal chain, improving accuracy over the entire voltage sensing range of interest. The TPS4141-Q1 supports uni-directional or bi-directional voltage measurement. Supplying an external precision voltage reference from REF to HVGND supports bi-directional voltage measurement. Switching between bi-directional and uni-directional voltage sensing during operation is possible using DIV0 and DIV1. Connecting REF to HVGND provides uni-directional voltage sensing only. The TPS4141-Q1 integrates a high-voltage switch with a standoff voltage greater than 1200V from the high-voltage sense pin (HV) to ground (HVGND). The switch provides uni-directional current blocking from HV to HVGND when disconnected.