The 8-bit AFE439A2, 10-bit AFE539A4, and 12-bit AFE639D2 ( AFEx39xx) are smart analog front ends (AFE) for thermoelectric cooling (TEC) control using voltage or PWM output. The AFE639D2 supports an I 2C controller interface to interface with external digital temperature sensors. The AFE639D2 and AFE539A4 support voltage output and AFE439A2 supports PWM output. The AFEx39xx support a comparator channel for fault management. These devices also support Hi-Z power-down mode and Hi-Z output on the DAC channel during power off. These devices have an integrated state machine that is preprogrammed as a proportional-integral (PI) controller. The AFEx39xx are an excellent choice for TEC control, temperature control, and dynamic headroom control applications. The AFEx39xx integrate advanced features, internal reference, and NVM that enable this smart AFE for processor-less applications and design reuse.