The OPA486, OPA2486, and OPA4486 (OPAx486) are a family of 48V, low noise, wide-bandwidth, low power, zero-drift operational amplifiers (op amps). The OPAx486 are a pin compatible replacement to many industry standard amplifiers that can benefit from higher operating voltage. The 48V operating voltage and the 60V absolute maximum supply voltage rating enable robust circuit designs. These op amps feature a 5µV of input offset voltage (max) and 0.025µV/°C of input offset voltage drift (max) over a wide temperature range. The OPAx486 also provide common-mode and power supply rejection to enable high precision measurements under a variety of operating conditions. These devices are designed for both dc and ac applications with near-zero flicker noise, very low broadband noise, wide bandwidth, and high slew. The ac performance is achieved with relatively low quiescent current of 650µA (max) to maintain system power budget limits. The combination of ac and dc performance make the OPAx486 appropriate for a wide range of high precision end equipment like analog input modules, battery testers, precision instrumentation, and process control. This family of devices are equipped with a proprietary MUX-friendly input architecture to enhance performance in multichannel, multiplexed applications. The OPAx486 are available in industry standard packages as well as micro-size packages to fit even the most space-constrained applications. The devices are specified for operation from –40°C to +125°C.