The TMP9R01-SP (QML Class P) and TMP9R01-SEP (Radiation Tolerant, Space EP) are high-accuracy digital I2C temperature sensors integrating a 12-bit ADC, bias current sources, and calibration circuitry in a 10-pin VSSOP plastic package. The devices measure remote temperature by forcing a bias current through an external BJT or the integrated diode/junction of an FPGA, ADC, or ASIC, digitizing the resulting ΔVBE and reporting temperature with 0.0625°C resolution. An additional on-chip sensor provides local temperature measurement. The TMP9R01-SP and TMP9R01-SEP incorporate multiple calibration and protection features, including series-resistance cancellation, programmable non-ideality factor (η-Factor), offset correction, and programmable digital filter. Designers can set high- and low-temperature limits that drive the ALERT output for over-and-under temperature thermal protection. Up to 9 pin-selectable I2C/SMBus addresses allow multiple sensors on the same I2C bus. The devices are designed for multi-location spacecraft housekeeping, satellite telemetry, avionics, and other high-reliability applications that require precise, temperature sensing and with varying levels of radiation hardness. The TMP9R01-SP is also available as a functionally equivalent QMLV-RHA device: TMP461-SP.