The THS4531A device is a low-power, fully differential amplifier with input common-mode range below the negative rail and rail-to-rail output. The device is designed for low-power data acquisition systems and high-density applications where power consumption and dissipation is critical. The device features accurate output common-mode control that allows for DC coupling when driving analog-to-digital converters (ADCs). This control, coupled with the input common-mode range below the negative rail and rail-to-rail output, allows for easy interface from single-ended ground-referenced signal sources to successive-approximation registers (SARs), and delta-sigma (ΔΣ) ADCs using only single-supply 2.5-V to 5-V power. The THS4531A is also a valuable tool for general-purpose, low-power differential signal conditioning applications.