The ADS1220 is a precision, 24-bit, analog-to-digital converter (ADC) that offers many integrated features to reduce system cost and component count in applications measuring small sensor signals. The device features two differential or four single-ended inputs through a flexible input multiplexer (MUX), a low-noise, programmable gain amplifier (PGA), two programmable excitation current sources, a voltage reference, an oscillator, a low-side switch, and a precision temperature sensor. The device can perform conversions at data rates up to 2000 samples-per-second (SPS) with single-cycle settling. At 20SPS, the digital filter offers simultaneous 50Hz and 60Hz rejection for noisy industrial applications. The internal PGA offers gains up to 128. This PGA makes the ADS1220 designed for applications measuring small sensor signals, such as resistance temperature detectors (RTDs), thermocouples, thermistors, and resistive bridge sensors. The device supports measurements of pseudo- or fully-differential signals when using the PGA. Alternatively, the device can be configured to bypass the internal PGA while still providing high input impedance and gains up to 4, allowing for single-ended measurements. Power consumption is as low as 120µA when operating in duty-cycle mode with the PGA disabled. The ADS1220 is offered in a leadless VQFN-16 or a TSSOP-16 package and is specified over a temperature range of –40°C to +125°C.