The AFE0256 is a 256-channel analog front-end (AFE) designed to suit the requirements of flat-panel detector (FPD)-based digital x-ray systems. The device includes 256 integrators, a programmable gain amplifier (PGA) for full-scale charge level selection, a correlated double sampler (CDS) with dual banking, 256:4 analog multiplexers, and four differential output drivers. The device also features four 14-bit successive-approximation register (SAR) analog-to-digital converters (ADCs) on board. Serial data from the ADCs are available in SPI format. Hardware-selectable integration polarity allows positive or negative charge integration and provides more flexibility in system design. The Nap feature enables substantial power saving that is especially useful in battery-powered systems. The AFE0256 is available as a 22-mm × 5-mm singulated format with known good gold-bump dies.