The THS4541-Q1 is a low-power, voltage-feedback, fully differential amplifier (FDA) with an input common-mode range less than the negative rail, and rail-to-rail output. Designed for low-power data acquisition systems where high density is critical in a high-performance analog-to-digital converter (ADC) or digital-to-analog converter (DAC) interface design. The THS4541-Q1 features the negative-rail input required when interfacing a dc-coupled, ground-centered, source signal. This negative-rail input, with rail-to-rail output, allows for an easy interface between single-ended, ground-referenced, bipolar signal sources and a wide variety of successive approximation register (SAR), delta-sigma (ΔΣ), or pipeline ADCs using only a single 2.7V to 5.4V power supply. The THS4541-Q1 is characterized for operation over the wide temperature range of –40°C to +125°C and is available in a 16-pin VQFN package, both with and without wettable flanks. The package with wettable flanks eases post-assembly visual inspection and is available as the THS4541W-Q1.